Purified recombinant human CD64

This recombinant monoclonal antibody can detects endogenous levels of CD64 protein.

FCGR1A FCG1 FCGR1 IGFR1

High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)

High affinity immunoglobulin gamma Fc receptor I ;
IgG Fc receptor I ;
Fc-gamma RI ;
FcRI ;
Fc-gamma RIA ;
FcgammaRIa ;
CD antigen CD64 ;

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008],

Function:High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.,online information:FCGR1A mutation db,PTM:N-glycosylated.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the immunoglobulin superfamily. FCGR1 family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Stabilized at the cell membrane through interaction with FCER1G.,subunit:Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL.,tissue specificity:Monocyte/macrophage specific.,

Cell membrane ; Single-pass type I membrane protein . Stabilized at the cell membrane through interaction with FCER1G.

Monocyte/macrophage specific.

>>Phagosome ;
>>Osteoclast differentiation ;
>>Neutrophil extracellular trap formation ;
>>Hematopoietic cell lineage ;
>>Fc gamma R-mediated phagocytosis ;
>>Leishmaniasis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia ;
>>Systemic lupus erythematosus