Synthesized peptide derived from human PMEL AA range: 400-500

The antibody can specifically recognize human PMEL protein.

PMEL D12S53E PMEL17 SILV

95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage specific antigen GP100;Melanocyte protein mel 17;Melanocyte protein Pmel 17;Melanocyte protein Pmel 17 precursor;Melanocytes lineage-specific antigen GP100;Melanoma associated ME20 antigen;Melanoma gp100;Melanoma-associated ME20 antigen;Melanosomal matrix protein 17;Melanosomal matrix protein17;P1;p100;p26;PMEL 17;PMEL;PMEL_HUMAN;PMEL17;Premelanosome protein;Secreted melanoma-associated ME20 antigen;SI;SIL;SILV;Silver (mouse homolog) like;Silver homolog;Silver locus protein homolog;Silver, mouse, homolog of

95 kDa melanocyte specific secreted glycoprotein ;
95 kDa melanocyte-specific secreted glycoprotein ;
D12S53E ;
gp100 ;
M-beta ;
ME20 ;
ME20 M/ME20 S ;
ME20-M ;
ME20-S ;
ME20M ;
ME20M/ME20S ;
ME20S ;
Melanocyte lineage specific antigen GP100 ;
Melanocyte protein mel 17 ;
Melanocyte protein Pmel 17 ;
Melanocyte protein Pmel 17 precursor ;
Melanocytes lineage-specific antigen GP100 ;
Melanoma associated ME20 antigen ;
Melanoma gp100 ;
Melanoma-associated ME20 antigen ;
Melanosomal matrix protein 17 ;
Melanosomal matrix protein17 ;
P1 ;
p100 ;
p26 ;
PMEL 17 ;
PMEL ;
PMEL_HUMAN ;
PMEL17 ;
Premelanosome protein ;
Secreted melanoma-associated ME20 antigen ;
SI ;
SIL ;
SILV ;
Silver ;
mouse homolog ;
like ;
Silver homolog ;
Silver locus protein homolog ;
HMB45 ;

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes , which are the melanin-producing organelles in melanocytes , and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq , Jan 2011] ,

Function:Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form , ME20-S , could protect tumor cells from antibody mediated immunity. ,similarity:Belongs to the Pmel-17/NMB family. ,similarity:Contains 1 PKD domain. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subcellular location:Probably product of proteolytic cleavage. ,tissue specificity:Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. ,

Cytoplasmic