TCL1 (ABT234) IHC kit
-IHCM6911
主要信息
Target
TCL1
Host Species
Mouse
Conjugate/Modification
Unmodified
货号: IHCM6911
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
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详细信息
特异性
The antibody can specifically recognize human TCL1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT234
同种型
IgG2a, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human TCL1 AA range: 50-114
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特异性:
The antibody can specifically recognize human TCL1 protein.
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基因名称:
TCL1A TCL1
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蛋白名称:
TCL1
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别名:
T-cell leukemia/lymphoma protein 1A ;
Oncogene TCL-1 ;
Oncogene TCL1 ;
Protein p14 TCL1 ;
Oncogene TCL-1 ;
Oncogene TCL1 ;
Protein p14 TCL1 ;
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背景:
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia , in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. , 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells , but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al. , 2000 [PubMed 10983986]) .[supplied by OMIM , Jul 2010] ,
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功能:
Disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL) . Translocation t (14;14) (q11;q32) ; translocation t (7;14) (q35;q32) ; inversion inv (14) (q11;q32) that involves the T-cell receptor alpha/delta locuses. ,Function:Enhances the phosphorylation and activation of AKT1 , AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation , stabilizes mitochondrial membrane potential and promotes cell survival. ,similarity:Belongs to the TCL1 family. ,subcellular location:Microsomal fraction. ,subunit:Homodimer. Interacts with AKT1 , AKT2 and AKT3 (via PH domain) . Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. ,tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. ,
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细胞定位:
Cytoplasmic , Nuclear
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研究领域:
>>PI3K-Akt signaling pathway
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文献引用（{{totalcount}}）
货号: IHCM6911
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
加入购物车
已收藏
收藏
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