Synthesized peptide derived from human GLUT-1 AA range: 400-492

The antibody can specifically recognize human GLUT-1 protein.

SLC2A1 GLUT1

Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)

This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface , where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq , Apr 2013] ,

Disease:Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]; also called blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures , delayed development , and acquired microcephaly. ,Disease:Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction , often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic , choreoathetotic , and ballistic movements may be associated with macrocytic hemolytic anemia. ,Function:Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. ,online information:GLUT1 entry ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. ,subcellular location:Localizes primarily at the cell surface (By similarity) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,tissue specificity:Expressed at variable levels in many human tissues. ,

Membranous

>>HIF-1 signaling pathway ;
>>Insulin secretion ;
>>Thyroid hormone signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Glucagon signaling pathway ;
>>Insulin resistance ;
>>Bile secretion ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Renal cell carcinoma ;
>>Central carbon metabolism in cancer ;
>>Diabetic cardiomyopathy