CD35 (ABT-CD35) IHC kit
-IHCM6280
主要信息
Target
CD35
Host Species
Mouse
Conjugate/Modification
Unmodified
货号: IHCM6280
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
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详细信息
特异性
The antibody can specifically recognize human CD35 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-CD35
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human CD35 AA range: 300-400
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特异性:
The antibody can specifically recognize human CD35 protein.
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基因名称:
CR1 C3BR
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蛋白名称:
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
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背景:
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes , leukocytes , glomerular podocytes , and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas , mesangiocapillary glomerulonephritis , systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting , conferring protection against severe malaria. Alternate allele-specific splice variants
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功能:
Function:Mediates cellular binding of particles and immune complexes that have activated complement. ,miscellaneous:This is the sequence of the F allotype of CR1. ,online information:Blood group antigen gene mutation database ,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting , a process associated with cerebral malaria , the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl (a) /Vil (Kn4 , or Swain-Langley; Vil or Villien) . Sl (a-) phenotype is more common in persons of African descent and may protect against fatal malaria. ,similarity:Belongs to the receptors of complement activation (RCA) family. ,similarity:Contains 30 Sushi (CCP/SCR) domains. ,subunit:Monomer. ,tissue specificity:Present on erythrocytes , leukocytes , glomerular podocytes , and splenic follicular dendritic cells. ,
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细胞定位:
Membranous
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研究领域:
>>Complement and coagulation cascades ;
>>Neutrophil extracellular trap formation ;
>>Hematopoietic cell lineage ;
>>Legionellosis ;
>>Leishmaniasis ;
>>Malaria ;
>>Tuberculosis
>>Neutrophil extracellular trap formation ;
>>Hematopoietic cell lineage ;
>>Legionellosis ;
>>Leishmaniasis ;
>>Malaria ;
>>Tuberculosis
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信号通路
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货号: IHCM6280
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
加入购物车
已收藏
收藏
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