Recombinant protein

This antibody detects endogenous levels of Cytokeratin 19 protein.

KRT19

CK19

Keratin,type I cytoskeletal 19 ;
Cytokeratin-19 ;
CK-19 ;
Keratin-19 ;
K19 ;

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members , this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm , the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq , Jul 2008] ,

developmental stage:Present in hair follicles at all stages of development. ,Domain:This keratin differs from all other IF proteins in lacking the C-terminal tail domain. ,Function:Involved in the organization of myofibers. Together with KRT8 , helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. ,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa) . ,similarity:Belongs to the intermediate filament family. ,subunit:Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. ,tissue specificity:Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells , bile ducts , gastrointestinal tract , bladder urothelium , oral epithelia , esophagus , ectocervical epithelium (at protein level) . Expressed in epidermal basal cells , in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord , and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. ,

Membranous , Cytoplasmic

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