Synthesized peptide derived from human Prostate-Specific Membrane Antigen (PSMA) AA range: 100-200

The antibody can specifically recognize human PSMA protein.

FOLH1 FOLH NAALAD1 PSM PSMA GIG27

Glutamate carboxypeptidase 2 (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase)

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates , including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate , central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates , resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alter

Alternative products:Experimental confirmation may be lacking for some isoforms ,Catalytic activity:Release of an unsubstituted , C-terminal glutamyl residue , typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. ,cofactor:Binds 2 zinc ions per subunit. Required for NAALADase activity. ,Domain:The NAALADase activity is found in the central region , the dipeptidyl peptidase IV type activity in the C-terminal. ,enzyme regulation:The NAALADase activity is inhibited by beta-NAAG , quisqualic acid , 2- (phosphonomethyl) pentanedioic acid (PMPA) and EDTA. Activated by cobalt. ,Function:Also exhibits a dipeptidyl-peptidase IV type activity. In vitro , cleaves Gly-Pro-AMC. ,Function:Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine , required for the uptake of folate. In the brain , modulates excitatory neurotransmission through the hydrolysis of the neuropeptide , N-aceylaspartylglutamate (NAAG) , thereby releasing glutamate. Isoforms PSM-4 and PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. ,induction:In the prostate , up-regulated in response to androgen deprivation. ,miscellaneous:PSMA is used as a diagnostic and prognostic indicator of prostate cancer , and as a possible marker for various neurological disorders such as schizophrenia , Alzheimer disease and Huntington disease. ,polymorphism:Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease , neural tube defects , and cognitive deficits. ,PTM:The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. ,PTM:The N-terminus is blocked. ,similarity:Belongs to the peptidase M28 family. M28B subfamily. ,tissue specificity:Highly expressed in prostate epithelium. Also expressed , in the small intestine , brain , kidney , liver , spleen , colon , trachea , spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain , highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. In the prostate , the PSMA' cytosolic isoform is the most abundant form in normal tissue , the membrane-bound PSMA-1 form in primary prostate tumors. The PSMA-2 isoform also found in normal prostate as well as in brain and liver. ,

Cytoplasmic , Membranous

>>Alanine , aspartate and glutamate metabolism ;
>>Metabolic pathways ;
>>Vitamin digestion and absorption