BOB.1 (ABT-BOB1) IHC kit
-IHCM6111
主要信息
Target
BOB.1
Host Species
Mouse
Conjugate/Modification
Unmodified
货号: IHCM6111
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
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详细信息
特异性
The antibody can specifically recognize human BOB.1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-BOB1
同种型
IgG2a, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human BOB.1 AA range: 150-256
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特异性:
The antibody can specifically recognize human BOB.1 protein.
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基因名称:
POU2AF1 OBF1
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蛋白名称:
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
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别名:
POU domain class 2-associating factor 1 ;
B-cell-specific coactivator OBF-1 ;
BOB-1 ;
OCA-B ;
OCT-binding factor 1 ;
B-cell-specific coactivator OBF-1 ;
BOB-1 ;
OCA-B ;
OCT-binding factor 1 ;
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背景:
BOB.1 is a transcription activating factor necessary for the formation of follicular germinal center and the production of immunoglobulin. It works together with Oct-2 and is highly expressed in granulocytes of spleen and peripheral blood. It is mainly used for the typing of Hodgkin's lymphoma , mainly nodular lymphocytes. Hodgkin's lymphoma is positive and classical Hodgkin's lymphoma is negative.
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功能:
Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with BCL6. ,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent , that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. ,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. ,similarity:Belongs to the POU2AF1 family. ,tissue specificity:B-cell specific. ,
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细胞定位:
Nuclear , Cytoplasmic
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文献引用（{{totalcount}}）
货号: IHCM6111
规格
价格
货期
数量
100mL
￥14,800.00
一周
0
10mL
￥1,780.00
一周
0
3mL
￥780.00
一周
0
加入购物车
已收藏
收藏
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