CD181 (PTF0106) Mouse mAb
-YF0116
主要信息
Target
IL-8RA
Host Species
Mouse
Reactivity
Human
Applications
FC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
组成
PBS, pH 7.4
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
浓度
0.5mg/ml
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTF0106
同种型
Mouse IgG2b/Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
CXCR1 CMKAR1 IL8RA
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蛋白名称:
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
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别名:
C-X-C chemokine receptor type 1 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
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背景:
C-X-C motif chemokine receptor 1(CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008],
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功能:
Function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
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细胞定位:
Cell membrane; Multi-pass membrane protein.
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组织表达:
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
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信号通路
Organismal Systems >> Immune system >> Chemokine signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
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