详细信息
推荐稀释比
Reconstitute in sterile water for a stock solution
组成
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
来源
E.coli
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
抗原&靶点信息
序列:
A DNA sequence encoding the human FGF1(Phe16~Asp155) was fused with the C-terminal His Tag
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别名:
FGFA,aFGF,ECGF,HBGF-1
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细胞定位:
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. .
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组织表达:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
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信号通路
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Melanoma
Human Diseases >> Cancer: specific types >> Breast cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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