AMBRA1 Rabbit pAb
-YT5762
主要信息
Target
AMBRA1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
140kD (Observed)
Conjugate/Modification
Unmodified
货号: YT5762
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:10000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
AMBRA1 Polyclonal Antibody detects endogenous levels of AMBRA1
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
140kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthetic Peptide of AMBRA1
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特异性:
AMBRA1 Polyclonal Antibody detects endogenous levels of AMBRA1
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基因名称:
AMBRA1 KIAA1736
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蛋白名称:
AMBRA1
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别名:
autophagy/beclin-1 regulator 1
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背景:
function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.,similarity:Contains 3 WD repeats.,subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.,
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功能:
Function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.,similarity:Contains 3 WD repeats.,subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.,
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细胞定位:
Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome . Mitochondrion . Cytoplasm, cytosol . Nucleus . Cell junction, focal adhesion . Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139). Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139). Partially localizes at mitochondria in normal conditions (PubMed:21358617). Localizes also to discrete punctae along the ciliary axoneme (By similarity). .
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组织表达:
Brain,Testis,
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研究领域:
>>Mitophagy - animal ;
>>Autophagy - animal ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases
>>Autophagy - animal ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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货号: YT5762
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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