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EDA Rabbit pAb

-YT5703

2 5
主要信息
Target

EDA

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB, IHC, IF, ELISA

MW

42kD (Observed)

Conjugate/Modification

Unmodified

货号: YT5703
规格
价格
货期
数量
200μL
¥3,780.00
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0

100μL
¥2,300.00
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40μL
¥960.00
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0

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详细信息
推荐稀释比
WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
EDA Polyclonal Antibody detects endogenous levels of EDA protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
42kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human EDA. AA range:120-170
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特异性:
EDA Polyclonal Antibody detects endogenous levels of EDA protein.
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基因名称:
EDA
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蛋白名称:
Ectodysplasin-A
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别名:
EDA ;
ED1 ;
EDA2 ;
Ectodysplasin-A ;
Ectodermal dysplasia protein ;
EDA protein
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数据库链接:
Organism 基因 ID SwissProt
Human 1896; Q92838;
Mouse 13607; O54693;
背景:
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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功能:
Alternative products:Additional isoforms seem to exist,Disease:Defects in EDA are a cause of hypodontia [MIM:300606]. Hypodontia is agenesis of two or more permanent teeth without associated systemic disorders. Hypodontia due to EDA defects is an X-linked recessive disorder. Affected individuals have normal hair, skin, and nails, but lack primary and permanent teeth.,Disease:Defects in EDA are the cause of ectodermal dysplasia, type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.,Function:Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor XEDAR.,PTM:N-glycosylated.,PTM:Processing by furin produces a secreted form.,similarity:Belongs to the tumor necrosis factor family.,similarity:Contains 1 collagen-like domain.,subunit:Homotrimer. The homotrimers may then dimerize and form higher order oligomers.,tissue specificity:Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.,
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细胞定位:
Cell membrane ; Single-pass type II membrane protein .; [Ectodysplasin-A, secreted form]: Secreted .
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组织表达:
Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>NF-kappa B signaling pathway
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货号: YT5703
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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