CD116 Rabbit pAb
-YT5262
主要信息
Target
CD116
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
44kD (Observed)
Conjugate/Modification
Unmodified
货号: YT5262
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
CD116 Polyclonal Antibody detects endogenous levels of CD116 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
44kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
RRID号
AB_3712886
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human CSF2RA. AA range:121-170
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特异性:
CD116 Polyclonal Antibody detects endogenous levels of CD116 protein.
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基因名称:
CSF2RA
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蛋白名称:
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
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别名:
CSF2RA ;
CSF2R ;
CSF2RY ;
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha ;
GM-CSF-R-alpha ;
GMCSFR-alpha ;
GMR-alpha ;
CDw116 ;
CD116
CSF2R ;
CSF2RY ;
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha ;
GM-CSF-R-alpha ;
GMCSFR-alpha ;
GMR-alpha ;
CDw116 ;
CD116
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背景:
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 , a cytokine which controls the production , differentiation , and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene , with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq , Jul 2008] ,
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功能:
Domain:The box 1 motif is required for JAK interaction and/or activation. ,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,Function:Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation , differentiation , and functional activation of hematopoietic cells. ,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. ,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily. ,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3 , IL5 and GM-CSF receptors. ,
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细胞定位:
Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 6]: Secreted .
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>JAK-STAT signaling pathway ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer
>>JAK-STAT signaling pathway ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer
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信号通路
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
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货号: YT5262
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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