STAT6 Rabbit pAb
-YT4454
主要信息
Target
Stat6
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, IHC, IF, ELISA
MW
94kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4454
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
94kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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ELISA Kits
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human STAT6. AA range:608-657
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特异性:
Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
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基因名称:
STAT6
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蛋白名称:
Signal transducer and activator of transcription 6
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别名:
STAT6 ;
Signal transducer and activator of transcription 6 ;
IL-4 Stat
Signal transducer and activator of transcription 6 ;
IL-4 Stat
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背景:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors , STAT family members are phosphorylated by the receptor associated kinases , and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L) , which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells , expression of cell surface markers , and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq , May 2010] ,
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功能:
Function:Carries out a dual Function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. ,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity) . Interacts with NCOA1 via its C-terminal LXXLL motif. ,
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细胞定位:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
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组织表达:
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研究领域:
>>Necroptosis ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Inflammatory bowel disease
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Inflammatory bowel disease
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信号通路
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Immune disease >> Inflammatory bowel disease
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
文献引用（{{totalcount}}）
货号: YT4454
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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