PIP5KIII Rabbit pAb
-YT3734
主要信息
Target
PIP5K
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF
MW
237kD (Observed)
Conjugate/Modification
Unmodified
货号: YT3734
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000;
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
PIP5KIII Polyclonal Antibody detects endogenous levels of PIP5KIII protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
237kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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PIP5KIII Rabbit pAb
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ELISA Kits
Total PIP5K Cell-Based Colorimetric ELISA Kit
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PIP5K. AA range:71-120
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特异性:
PIP5KIII Polyclonal Antibody detects endogenous levels of PIP5KIII protein.
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基因名称:
PIKFYVE
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蛋白名称:
1-phosphatidylinositol 3-phosphate 5-kinase
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别名:
PIKFYVE ;
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
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背景:
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf
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功能:
Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,Disease:Defects in PIKFYVE are the cause of corneal fleck dystrophy (CFD) [MIM:121850]. CFD is an autosomal dominant disorder of the cornea characterized by numerous small white flecks scattered in all levels of the stroma. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision.,Function:Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P(2) pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P(2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking.,similarity:Contains 1 DEP domain.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 PI5K domain.,subcellular location:Mainly associated with membranes of the late endocytic pathway.,
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细胞定位:
Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Mainly associated with membranes of the late endocytic pathway. .
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组织表达:
研究领域:
>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
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信号通路
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货号: YT3734
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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