The antiserum was produced against synthesized peptide derived from human MGST3. AA range:8-57

MGST3 Polyclonal Antibody detects endogenous levels of MGST3 protein.

MGST3

Microsomal glutathione S-transferase 3

MGST3 ;
Microsomal glutathione S-transferase 3 ;
Microsomal GST-3 ;
Microsomal GST-III

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011],

Catalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Also functions as a glutathione peroxidase.,similarity:Belongs to the MAPEG family.,tissue specificity:Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.,

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein . Microsome membrane ; Lipid-anchor . Membrane .

>>Glutathione metabolism ;
>>Metabolism of xenobiotics by cytochrome P450 ;
>>Drug metabolism - cytochrome P450 ;
>>Drug metabolism - other enzymes ;
>>Metabolic pathways ;
>>Platinum drug resistance ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - DNA adducts ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Hepatocellular carcinoma ;
>>Fluid shear stress and atherosclerosis