The antiserum was produced against synthesized peptide derived from human Fas. AA range:257-306

Fas Polyclonal Antibody detects endogenous levels of Fas protein.

FAS

Tumor necrosis factor receptor superfamily member 6

FAS ;
APT1 ;
FAS1 ;
TNFRSF6 ;
Tumor necrosis factor receptor superfamily member 6 ;
Apo-1 antigen ;
Apoptosis-mediating surface antigen FAS ;
FASLG receptor ;
CD95

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death , and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD) , caspase 8 , and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade , and leads to apoptosis. This receptor has been also shown to activate NF-kappaB , MAPK3/ERK1 , and MAPK8/JNK , and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described , s

Disease:Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS) . ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. ,Domain:Contains a death domain involved in the binding of FADD , and maybe to other cytosolic adapter proteins. ,Function:Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . ,online information:Mutations in TNFRSF6 causing ALPS type Ia ,similarity:Contains 1 death domain. ,similarity:Contains 3 TNFR-Cys repeats. ,subunit:Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity) . Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. ,tissue specificity:Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. ,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Membrane raft .; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.

>>Platinum drug resistance ;
>>MAPK signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Necroptosis ;
>>Natural killer cell mediated cytotoxicity ;
>>TNF signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>Alcoholic liver disease ;
>>Type I diabetes mellitus ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Chagas disease ;
>>African trypanosomiasis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Autoimmune thyroid disease ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Lipid and atherosclerosis