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DAN Rabbit pAb

-YT1284

2 5
主要信息
Target

DAN

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

WB, IHC, IF, ELISA

MW

19kD (Observed)

Conjugate/Modification

Unmodified

货号: YT1284
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
DAN Polyclonal Antibody detects endogenous levels of DAN protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
19kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human NBL1. AA range:131-180
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特异性:
DAN Polyclonal Antibody detects endogenous levels of DAN protein.
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基因名称:
NBL1
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蛋白名称:
Neuroblastoma suppressor of tumorigenicity 1
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别名:
NBL1 ;
DAN ;
DAND1 ;
Neuroblastoma suppressor of tumorigenicity 1 ;
DAN domain family member 1 ;
Protein N03 ;
Zinc finger protein DAN
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数据库链接:
Organism 基因 ID SwissProt
Human 4681;100532736; P41271;
Mouse Q61477;
背景:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013],
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功能:
Disease:Defects in NBL1 are possibly the cause of the development and/or progression of human neuroblastoma.,Function:Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,tissue specificity:Most abundant in normal lung and meningioma.,
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细胞定位:
Secreted.
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组织表达:
Most abundant in normal lung and meningioma.
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研究领域:
>>TGF-beta signaling pathway
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货号: YT1284
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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