The antiserum was produced against synthesized peptide derived from human ADCY8. AA range:591-640

A Cyclase VIII Polyclonal Antibody detects endogenous levels of A Cyclase VIII protein.

ADCY8

Adenylate cyclase type 8

ADCY8 ;
Adenylate cyclase type 8 ;
ATP pyrophosphate-lyase 8 ;
Adenylate cyclase type VIII ;
Adenylyl cyclase 8 ;
AC8 ;
Ca ;
2+ ;
/calmodulin-activated adenylyl cyclase

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008],

Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin.,Function:This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Apical cell membrane . Cell junction, synapse . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, postsynaptic density . Membrane raft . Membrane, coated pit . Cytoplasmic vesicle, clathrin-coated vesicle membrane . Membrane, caveola . Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity). .

Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).

>>Purine metabolism ;
>>Metabolic pathways ;
>>Endocrine resistance ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Oocyte meiosis ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>GABAergic synapse ;
>>Taste transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Ovarian steroidogenesis ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Oxytocin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Bile secretion ;
>>Morphine addiction ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Dilated cardiomyopathy