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p38-γ/δ (Phospho Tyr185/182) Rabbit pAb

-YP1718

5 4 2
主要信息
Target

p38-γ/δ

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

MW

40kD (Calculated)

Conjugate/Modification

Phospho

货号: YP1718
规格
价格
货期
数量
200μL
¥4,680.00
两周

0

100μL
¥2,800.00
两周

0

50μL
¥1,500.00
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0

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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of p38-γ/δ only when phosphorylated at Tyr185 or thr182,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TGyVV
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
40kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human p38-γ/δ (Phospho-Tyr185/182)
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特异性:
This antibody detects endogenous levels of p38-γ/δ only when phosphorylated at Tyr185 or thr182,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TGyVV
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基因名称:
MAPK12 ERK6 SAPK3
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蛋白名称:
p38-γ/δ (Phospho-Tyr185/182)
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别名:
Mitogen-activated protein kinase 12 ;
MAP kinase 12 ;
MAPK 12 ;
Extracellular signal-regulated kinase 6 ;
ERK-6 ;
Mitogen-activated protein kinase p38 gamma ;
MAP kinase p38 gamma ;
Stress-activated protein kinase 3 ;
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数据库链接:
Organism 基因 ID SwissProt
Human 6300; P53778;
Mouse 29857; O08911;
Rat 60352; Q63538;
背景:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 magnesium ions.,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by phosphorylation on threonine and tyrosine.,Function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Mitochondrial when associated with SH3BP5.,subunit:Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5.,tissue specificity:Highly expressed in skeletal muscle and heart.,
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细胞定位:
Cytoplasm. Nucleus. Mitochondrion. Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). .
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组织表达:
Highly expressed in skeletal muscle and heart.
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研究领域:
>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>Rap1 signaling pathway ;
>>FoxO signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Oocyte meiosis ;
>>Cellular senescence ;
>>Adrenergic signaling in cardiomyocytes ;
>>VEGF signaling pathway ;
>>Osteoclast differentiation ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Thermogenesis ;
>>Neurotrophin signaling pathway ;
>>Retrograde endocannabinoid signaling ;
>>Dopaminergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>GnRH signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis, secretion and action ;
>>Alcoholic liver disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Yersinia infection ;
>>Leishmaniasis ;
>>Chagas disease ;
>>Toxoplasmosis ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis
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信号通路
Cellular Processes >> Cell growth and death >> Cellular senescence Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells Organismal Systems >> Immune system >> Platelet activation Organismal Systems >> Immune system >> Neutrophil extracellular trap formation Organismal Systems >> Immune system >> Toll-like receptor signaling pathway Organismal Systems >> Immune system >> NOD-like receptor signaling pathway Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway Organismal Systems >> Immune system >> T cell receptor signaling pathway Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation Organismal Systems >> Immune system >> Th17 cell differentiation Organismal Systems >> Immune system >> IL-17 signaling pathway Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway Organismal Systems >> Immune system >> Leukocyte transendothelial migration Organismal Systems >> Endocrine system >> GnRH signaling pathway Organismal Systems >> Endocrine system >> Prolactin signaling pathway Organismal Systems >> Endocrine system >> Relaxin signaling pathway Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes Organismal Systems >> Nervous system >> Dopaminergic synapse Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels Organismal Systems >> Development and regeneration >> Osteoclast differentiation Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis Human Diseases >> Neurodegenerative disease >> Prion disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway Environmental Information Processing >> Signal transduction >> VEGF signaling pathway Environmental Information Processing >> Signal transduction >> TNF signaling pathway Environmental Information Processing >> Signal transduction >> FoxO signaling pathway Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
货号: YP1718
规格
价格
货期
数量
200μL
¥4,680.00
两周

0

100μL
¥2,800.00
两周

0

50μL
¥1,500.00
两周

0

加入购物车

已收藏

收藏

定制服务咨询

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