MAP3K2 (Phospho Ser520) Rabbit pAb
-YP1703
主要信息
Target
MAP3K2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
68kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1703
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MAP3K2 (Phospho-Ser520) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MKsVT
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
68kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human MAP3K2 (Phospho-Ser520)
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特异性:
This antibody detects endogenous levels of MAP3K2 (Phospho-Ser520) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MKsVT
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基因名称:
MAP3K2 MAPKKK2 MEKK2
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蛋白名称:
MAP3K2 (Phospho-Ser520)
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别名:
Mitogen-activated protein kinase kinase kinase 2 ;
MAPK/ERK kinase kinase 2 ;
MEK kinase 2 ;
MEKK 2 ;
MAPK/ERK kinase kinase 2 ;
MEK kinase 2 ;
MEKK 2 ;
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背景:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,Function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
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细胞定位:
Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.
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组织表达:
Brain,Platelet,T-cell,Teratocarcinoma,Whole embryo,
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研究领域:
>>MAPK signaling pathway ;
>>Gap junction ;
>>GnRH signaling pathway
>>Gap junction ;
>>GnRH signaling pathway
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信号通路
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货号: YP1703
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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