Synthesized phosho peptide around human PAK2 (Ser20)

This antibody detects endogenous levels of Human Mouse PAK2 (phospho-Ser20)

PAK2

PAK2 (Ser19)

PAK2 ;
Serine/threonine-protein kinase PAK 2 ;
Gamma-PAK ;
PAK65 ;
S6/H4 kinase ;
p21-activated kinase 2 ;
PAK-2 ;
p58

Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). .

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Axon guidance ;
>>Hippo signaling pathway - multiple species ;
>>Focal adhesion ;
>>C-type lectin receptor signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Human immunodeficiency virus 1 infection ;
>>Proteoglycans in cancer ;
>>Renal cell carcinoma