CARD11 (Phospho Ser652) Rabbit pAb
-YP1286
主要信息
Target
CARD11 Phospho Ser652
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
130kD (Observed)
Conjugate/Modification
Phospho
货号: YP1286
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
130kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human CARD11 (Ser652)
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特异性:
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
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基因名称:
CARD11 CARMA1
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蛋白名称:
Caspase recruitment domain-containing protein 11
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别名:
CARD11 ;
CARMA1 ;
Caspase recruitment domain-containing protein 11 ;
CARD-containing MAGUK protein 1 ;
Carma 1
CARMA1 ;
Caspase recruitment domain-containing protein 11 ;
CARD-containing MAGUK protein 1 ;
Carma 1
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背景:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],
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功能:
Caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,Function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,
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细胞定位:
Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
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研究领域:
>>NF-kappa B signaling pathway ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway
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信号通路
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货号: YP1286
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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