The antiserum was produced against synthesized peptide derived from human CD18/ITGB2 around the phosphorylation site of Thr758. AA range:720-769

Phospho-Integrin β2 (T758) Polyclonal Antibody detects endogenous levels of Integrin β2 protein only when phosphorylated at T758.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SAtTT

ITGB2

Integrin beta-2

ITGB2 ;
CD18 ;
MFI7 ;
Integrin beta-2 ;
Cell surface adhesion glycoproteins LFA-1/CR3/p150 ;
95 subunit beta ;
Complement receptor C3 subunit beta ;
CD antigen CD18

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.,

Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).

>>Rap1 signaling pathway ;
>>Phagosome ;
>>Hippo signaling pathway ;
>>Cell adhesion molecules ;
>>Complement and coagulation cascades ;
>>Neutrophil extracellular trap formation ;
>>Natural killer cell mediated cytotoxicity ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Pertussis ;
>>Legionellosis ;
>>Leishmaniasis ;
>>Malaria ;
>>Amoebiasis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Human T-cell leukemia virus 1 infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis