MAPKAPK5 (Phospho Thr182) Rabbit pAb
-YP0820
主要信息
Target
MAPKAPK5 Phospho Thr182
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Phospho
货号: YP0820
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-PRAK (T182) Polyclonal Antibody detects endogenous levels of PRAK protein only when phosphorylated at T182.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LMtPQ
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Primary Antibodies
MAPKAPK5 Rabbit pAb
YT3848
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Primary Antibodies
MAPKAPK5 (Phospho Thr182) Rabbit pAb
YP0820
预览→
ELISA Kits
Total MAPKAPK5 Cell-Based Colorimetric ELISA Kit
KA4169C
预览→
ELISA Kits
MAPKAPK5 (Phospho Thr182) Cell-Based Colorimetric ELISA Kit
KA1752C
预览→
抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Thr182. AA range:148-197
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特异性:
Phospho-PRAK (T182) Polyclonal Antibody detects endogenous levels of PRAK protein only when phosphorylated at T182.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LMtPQ
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基因名称:
MAPKAPK5
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蛋白名称:
MAP kinase-activated protein kinase 5
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别名:
MAPKAPK5 ;
PRAK ;
MAP kinase-activated protein kinase 5 ;
MAPK-activated protein kinase 5 ;
MAPKAP kinase 5 ;
MAPKAP-K5 ;
MAPKAPK-5 ;
MK-5 ;
MK5 ;
p38-regulated/activated protein kinase ;
PRAK
PRAK ;
MAP kinase-activated protein kinase 5 ;
MAPK-activated protein kinase 5 ;
MAPKAP kinase 5 ;
MAPKAP-K5 ;
MAPKAPK-5 ;
MK-5 ;
MK5 ;
p38-regulated/activated protein kinase ;
PRAK
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背景:
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:p38 alpha and beta-dependent phosphorylation increases its activity. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1.,Function:Mediates stress-induced small heat shock protein 27 phosphorylation.,PTM:Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Also observed in the nucleus.,subunit:Interacts with SQSTM1.,tissue specificity:Expressed ubiquitously.,
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细胞定位:
Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
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组织表达:
研究领域:
>>MAPK signaling pathway
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货号: YP0820
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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