eIF4B (Phospho Ser422) Rabbit pAb

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Western Blot IHC IF/ICC IP

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-YP0280

说明书

SDS

FAQ

主要信息

Target

eIF4B

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB, IHC, IF, ELISA

80kD (Observed)

Conjugate/Modification

Phospho

All {{item.name}}

货号: YP0280

规格

价格

货期

数量

200μL

￥4,680.00

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100μL

￥2,800.00

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50μL

￥1,500.00

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详细信息相关产品抗原&靶点信息信号通路

详细信息

推荐稀释比

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

特异性

Phospho-eIF4B (S422) Polyclonal Antibody detects endogenous levels of eIF4B protein only when phosphorylated at S422.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TGsES

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

实测条带

80kD

修饰

Phospho

克隆性

Polyclonal

同种型

IgG

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抗原&靶点信息

免疫原:

The antiserum was produced against synthesized peptide derived from human eIF4B around the phosphorylation site of Ser422. AA range:388-437

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特异性:

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基因名称:

EIF4B

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蛋白名称:

Eukaryotic translation initiation factor 4B

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别名:

EIF4B ;
Eukaryotic translation initiation factor 4B ;
eIF-4B

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数据库链接:

Organism	基因 ID	SwissProt
Human	3716;	P23588;
Mouse	75705;	Q8BGD9;

背景:

function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,

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功能:

Function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,

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细胞定位:

cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body,

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组织表达:

Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung

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研究领域:

>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Proteoglycans in cancer

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