Synthesized peptide derived from part region of human protein. AA range:908-1008

CERU Polyclonal Antibody detects endogenous levels of protein.

CP

Ceruloplasmin (Ferroxidase)

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II) transferrin to Fe (III) transferrin. Mutations in this gene cause aceruloplasminemia , which results in iron accumulation and tissue damage , and is associated with diabetes and neurologic abnormalities. Two transcript variants , one protein-coding and the other not protein-coding , have been found for this gene. [provided by RefSeq , Feb 2012] ,

Catalytic activity:4 Fe (2+) + 4 H (+) + O (2) = 4 Fe (3+) + 2 H (2) O. ,cofactor:Binds 6 copper ions per monomer. ,Disease:Ceruloplasmin levels are decreased in Wilson disease , in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. ,Disease:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration , diabetes mellitus and neurological disturbances. ,Function:Ceruloplasmin is a blue , copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe (2+) to Fe (3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. ,online information:Ceruloplasmin entry ,similarity:Belongs to the multicopper oxidase family. ,similarity:Contains 3 F5/8 type A domains. ,similarity:Contains 6 plastocyanin-like domains. ,tissue specificity:Expressed by the liver and secreted in plasma. ,

Secreted. Colocalizes with GCP1 in secretory intracellular compartments. .

>>Porphyrin metabolism ;
>>Ferroptosis