HSL (Phospho Ser853) (PT1168R) PT™ Rabbit mAb
-YM9017
主要信息
Target
HSL Phospho Ser853
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
117kD (Calculated)
83kD (Observed)
Conjugate/Modification
Phospho
货号: YM9017
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
HSL (Phospho Ser853)Antibody detects endogenous levels of HSL protein only when phosphorylated at S853.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RRsVS
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
117kD
实测条带
83kD
修饰
Phospho
克隆性
Monoclonal
克隆号
PT1168R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
HSL (Phospho Ser853)Antibody detects endogenous levels of HSL protein only when phosphorylated at S853.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RRsVS
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基因名称:
LIPE
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蛋白名称:
Hormone-sensitive lipase
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别名:
LIPE ;
Hormone-sensitive lipase ;
HSL
Hormone-sensitive lipase ;
HSL
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背景:
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.,Catalytic activity:Monoacylglycerol + H(2)O = glycerol + a carboxylate.,Catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.,Function:In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.,pathway:Glycerolipid metabolism; triacylglycerol degradation.,similarity:Belongs to the 'GDXG' lipolytic enzyme family.,subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with PTRF in the adipocyte cytoplasm.,
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细胞定位:
Cell membrane . Membrane, caveola . Cytoplasm, cytosol . Lipid droplet . Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity). .
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组织表达:
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研究领域:
>>cAMP signaling pathway ;
>>AMPK signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion
>>AMPK signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion
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信号通路
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
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货号: YM9017
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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