Phospho-CaMKIIα/β (T286) Antibody detects endogenous levels of CaMKIIα/β protein only when phosphorylated at T286.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QEtVD

CAMK2A

Calcium/calmodulin-dependent protein kinase type II subunit alpha

CAMK2A ;
CAMKA ;
KIAA0968 ;
Calcium/calmodulin-dependent protein kinase type II subunit alpha ;
CaM kinase II subunit alpha ;
CaMK-II subunit alpha ;
CAMK2B ;
CAM2 ;
CAMK2 ;
CAMKB ;
Calcium/calmodulin-dependent protein kinase type II subunit beta ;
Ca

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Postsynaptic lipid rafts.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.,

Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. .

Brain,

>>ErbB signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>HIF-1 signaling pathway ;
>>Oocyte meiosis ;
>>Necroptosis ;
>>Adrenergic signaling in cardiomyocytes ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Cholinergic synapse ;
>>Dopaminergic synapse ;
>>Olfactory transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Melanogenesis ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cushing syndrome ;
>>Gastric acid secretion ;
>>Parkinson disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Tuberculosis ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Glioma ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis