Cleaved N-terminal GSDMD (PT0680R) PT® Rabbit mAb
-YM8489
主要信息
Target
GSDMD
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IP, ELISA
MW
53kD (Calculated)
35kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8489
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of Cleaved N-terminal GSDMD.
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
53kD
实测条带
35kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0680R
同种型
IgG,Kappa
相关产品
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GSDME N-terminal Rabbit pAb
YT7990
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GSDME C-terminal Rabbit pAb
YT7989
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Primary Antibodies
Cleaved Caspase-1 p20 (Asp210) Rabbit pAb
YC0002
预览→
抗原&靶点信息
特异性:
This antibody detects endogenous levels of Cleaved N-terminal GSDMD.
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基因名称:
GSDMD
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蛋白名称:
Gasdermin domain-containing protein 1,Gasdermin-D,GSDMD,GSDMD-CT,GSDMD-NT,GSDMD_HUMAN
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数据库链接:
| Organism | 基因 ID | SwissProt |
|---|---|---|
| Human | P57764; |
功能:
Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147, PubMed:28045099).
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细胞定位:
[Gasdermin-D]: Cytoplasm, cytosol . Inflammasome . In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. .; [Gasdermin-D, N-terminal]: Cell membrane ; Multi-pass membrane protein . Secreted . Released in the extracellular milieu following pyroptosis. .; [Gasdermin-D, C-terminal]: Cytoplasm, cytosol .
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组织表达:
Expressed in the suprabasal cells of esophagus, as well as in the isthmus/neck, pit, and gland of the stomach, suggesting preferential expression in differentiating cells.
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研究领域:
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
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文献引用（{{totalcount}}）
货号: YM8489
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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