This antibody detects endogenous levels of Rsk-1 only when phosphorylated at Ser380.This antibody does not recognize phosphorylated at other sites.

RPS6KA1

Ribosomal protein S6 kinase alpha-1

RPS6KA1 ;
MAPKAPK1A ;
RSK1 ;
Ribosomal protein S6 kinase alpha-1 ;
S6K-alpha-1 ;
90 kDa ribosomal protein S6 kinase 1 ;
p90-RSK 1 ;
p90RSK1 ;
p90S6K ;
MAP kinase-activated protein kinase 1a ;
MAPK-activated protein kinase 1a ;
MAPKAP kinase 1a ;
MAPKAP

Ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,

Cytoplasm, Nucleus

Colon,Epithelium,

>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation