AIFM1 (PT0650R) PT™ Rabbit mAb
-YM8459
主要信息
Target
AIFM1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
67kD (Calculated)
67kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8459
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
67kD
实测条带
67kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0650R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
Endogenous
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基因名称:
AIFM1 ALF PDCD8
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蛋白名称:
Apoptosis-inducing factor 1 mitochondrial
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别名:
AIFM1 ;
AIF ;
PDCD8 ;
Apoptosis-inducing factor 1 ;
mitochondrial ;
Programmed cell death protein 8
AIF ;
PDCD8 ;
Apoptosis-inducing factor 1 ;
mitochondrial ;
Programmed cell death protein 8
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背景:
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells , and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition , this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6) , a severe mitochondrial encephalomyopathy , as well as Cowchock syndrome , also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4) , a disorder resulting in neuropathy , and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
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功能:
Catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol. ,cofactor:FAD. ,Function:Possesses significant protein thiol-disulfide oxidase activity. ,Function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro) . Binds to DNA in a sequence-independent manner. ,similarity:Belongs to the FAD-dependent oxidoreductase family. ,similarity:Contains 1 thioredoxin domain. ,subcellular location:Translocated to the nucleus upon induction of apoptosis. ,subunit:Interacts with XIAP. ,tissue specificity:Widely expressed. ,
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细胞定位:
Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm , perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit) . During apoptosis , further proteolytic processing leads to a mature form , which is confined to the mitochondrial IMS in a soluble form (AIFsol) . AIFsol is released to the cytoplasm in response to specific death signals , and translocated to the nucleus , where it induces nuclear apoptosis (PubMed:15775970) . Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969) . .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm , cytosol . In pro-apoptotic conditions , is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
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研究领域:
>>Apoptosis ;
>>Necroptosis
>>Necroptosis
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信号通路
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货号: YM8459
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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