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R

LAMP2 (PT0249R) PT™ Rabbit mAb

-YM8157

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主要信息
Target

LAMP2

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB, IHC, IF, ELISA

MW

45kD (Calculated)

120kD (Observed)

Conjugate/Modification

Unmodified

货号: YM8157
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
45kD
实测条带
120kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0249R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
LAMP2
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蛋白名称:
Lysosome-associated membrane glycoprotein 2
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别名:
LAMP2 ;
Lysosome-associated membrane glycoprotein 2 ;
LAMP-2 ;
Lysosome-associated membrane protein 2 ;
CD107 antigen-like family member B ;
CD107b
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数据库链接:
Organism 基因 ID SwissProt
Human 3920; P13473;
Mouse P17047;
背景:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008],
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功能:
Disease:Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.,Function:Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction.,PTM:O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.,similarity:Belongs to the LAMP family.,subcellular location:This protein shuttles between lysosomes, endosomes, and the plasma membrane.,tissue specificity:Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.,
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细胞定位:
Membranous
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研究领域:
>>Autophagy - animal ;
>>Lysosome ;
>>Phagosome ;
>>Tuberculosis
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货号: YM8157
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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