Claudin 4 (ABT-CLD4) Mouse mAb
-YM4922
主要信息
Target
Claudin-4
Host Species
Mouse
Reactivity
Human,
Applications
IHC, WB, IF, ELISA
MW
22kD (Calculated)
22kD (Observed)
Conjugate/Modification
Unmodified
货号: YM4922
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of Claudin 4 protein.
纯化工艺
Protein G
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
22kD
实测条带
22kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-CLD4
同种型
IgG2b,Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Claudin 4 AA range: 150-209
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特异性:
This antibody detects endogenous levels of Claudin 4 protein.
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基因名称:
CLDN4 CPER CPETR1 WBSCR8
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蛋白名称:
Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)
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背景:
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013],
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功能:
Disease:Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
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细胞定位:
Membranous
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组织表达:
Colon,Fetal brain,Trachea,
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研究领域:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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信号通路
文献引用（{{totalcount}}）
货号: YM4922
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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