Synthesized peptide derived from human GST-Pi AA range: 150-210

The antibody can specifically recognize human GST-Pi protein. In western blotting of Hela cell lysate, the antibody can label a 26 kDa band corresponding to GST-Pi.

GSTP1 FAEES3 GST3

Deafness;Deafness X-linked 7;DFN7;FAEES3;Fatty Acid Ethyl Ester Synthase III;Glutathione S Transferase 3;Glutathione S Transferase Pi;Glutathione S-transferase P;Glutathione S-transferase pi 1;GST class-pi;GST3;GSTP;Gstp1;GSTP1-1;GSTP1_HUMAN;PI;X linked 7

GSTP1 FAEES3 GST3

GST -Pi is a major isoenzyme in GST family. It widely exists in the cytoplasm and mitochondria of human organs and has detoxification function. At present, it is considered to be a marker of drug resistance in tumor cells. GST - Pi is highly expressed in a variety of tumors, which is related to tumor treatment drug resistance. The simultaneous detection of GST - Pi with P-gp and TopoII has more clinical significance for judging whether tumor cells produce drug resistance.

Catalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,

Cytoplasmic

Esophageal squamous cell carcinoma

>>Glutathione metabolism ;
>>Metabolism of xenobiotics by cytochrome P450 ;
>>Drug metabolism - cytochrome P450 ;
>>Drug metabolism - other enzymes ;
>>Metabolic pathways ;
>>Platinum drug resistance ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - DNA adducts ;
>>Prostate cancer ;
>>Hepatocellular carcinoma ;
>>Fluid shear stress and atherosclerosis