Synthesized peptide derived from human CD54 AA range: 100-200

The antibody can specifically recognize human CD54 protein.

ICAM1

Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

Antigen identified by monoclonal BB2 ;
BB 2 ;
BB2 ;
CD 54 ;
CD_antigen=CD54 ;
CD54 ;
Cell surface glycoprotein P3.58 ;
Human rhinovirus receptor ;
ICAM 1 ;
ICAM-1 ;
ICAM1 ;
ICAM1_HUMAN ;
intercellular adhesion molecule 1 ;
CD54 ;
intercellular adhesion molecule 1 ;
CD54 ;
, human rhinovirus receptor ;
Intercellular adhesion molecule 1 ;
Major group rhinovirus receptor ;
MALA 2 ;
MALA2 ;
MyD 10 ;
MyD10 ;
P3.58 ;
Surface antigen of activated B cells ;
Surface antigen of activated B cells, BB2

CD54, also known as ICAM-1, is a type I transmembrane protein. CD is expressed on activated endothelial cells, high endothelial venules, monocytes/macrophages, T and B cells, dendritic cells and granulocytes. It plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 is also detected in some carcinoma and melanoma cells. In patients with various inflammatory syndromes, the level of soluble CD54 is upregulated in plasma.

Function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,

Membranous

Blood,Kidney,Liver,Melanoma,Plasma,

>>NF-kappa B signaling pathway ;
>>Cell adhesion molecules ;
>>Natural killer cell mediated cytotoxicity ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>African trypanosomiasis ;
>>Malaria ;
>>Staphylococcus aureus infection ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis