p15 INK (PTR2192) Mouse mAb
-YM4531
主要信息
Target
CDKN2B
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, ELISA
MW
15kD (Calculated)
15kD (Observed)
Conjugate/Modification
Unmodified
货号: YM4531
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of p15 INK protein.
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
15kD
实测条带
15kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTR2192
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human p15 INK (PTR2192) AA range: 50-138
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特异性:
This antibody detects endogenous levels of p15 INK protein.
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基因名称:
CDKN2B MTS2
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蛋白名称:
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
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背景:
cyclin dependent kinase inhibitor 2B(CDKN2B) Homo sapiens This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],
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功能:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
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细胞定位:
Cytoplasmic
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信号通路
Cellular Processes >> Cell growth and death >> Cell cycle
Cellular Processes >> Cell growth and death >> Cellular senescence
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Small cell lung cancer
Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
文献引用（{{totalcount}}）
货号: YM4531
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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