Purified recombinant human PI3 Kinase p85 beta protein fragments expressed in E.coli.

This antibody detects endogenous levels of PI3 Kinase p85 beta and does not cross-react with related proteins.

pik3r2

p85 ;
p85 beta ;
p85-BETA ;
P85B ;
P85B_HUMAN ;
Phosphatidylinositol 3 kinase ;
Phosphatidylinositol 3 kinase regulatory beta subunit ;
Phosphatidylinositol 3 kinase regulatory subunit beta ;
Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 ;
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 ;
p85 beta ;
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta ;
phosphatidylinositol 3-kinase ;
Phosphatidylinositol 3-kinase regulatory beta subunit ;
Phosphatidylinositol 3-kinase regulatory subunit beta ;
Phosphoinositide 3 kinase regulatory subunit 2 ;
beta ;
Phosphoinositide 3 kinase regulatory subunit 2 ;
Phosphoinositide 3 kinase regulatory subunit polypeptide 2 ;
p85 beta ;
Phosphoinositide 3 kinase regulatory subunit polypeptide 2 ;
Phosphoinositide 3 kinase, regulatory subunit 2 ;
beta ;
Phosphoinositide 3 kinase, regulatory subunit 2 ;
p85 beta ;
PI3 kinase p85 beta subunit ;
PI3 kinase p85 subunit beta ;
PI3-kinase regulatory subunit beta ;
PI3-kinase subunit p85-beta ;
PI3K ;
PI3K regulatory subunit beta ;
PIK3R 2 ;
PIK3R2 ;
polypeptide 2 ;
p85 beta ;
PtdIns 3 kinase p85 beta ;
PtdIns-3-kinase p85-beta ;
PtdIns-3-kinase regulatory subunit beta ;
PtdIns-3-kinase regulatory subunit p85-beta.

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012],

Function:Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.,

nucleus,cytosol,phosphatidylinositol 3-kinase complex,

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>Platinum drug resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>HIF-1 signaling pathway ;
>>FoxO signaling pathway ;
>>Phosphatidylinositol signaling system ;
>>Sphingolipid signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Apoptosis ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Cellular senescence ;
>>Axon guidance ;
>>VEGF signaling pathway ;
>>Osteoclast differentiation ;
>>Focal adhesion ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>Toll-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>Fc gamma R-mediated phagocytosis ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Neurotrophin signaling pathway ;
>>Cholinergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>Regulation of actin cytoskeleton ;
>>Insulin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Relaxin signaling pathway ;
>>GnRH secretion ;
>>Type II diabetes mellitus ;
>>Insulin resistance ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis, secretion and action ;
>>Aldosterone-regulated sodium reabsorption ;
>>Carbohydrate digestion and absorption ;
>>Alzheimer disease ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Bacterial invasion of epithelial cells ;
>>Shigellosis ;
>>Yersinia infection ;
>>Chagas disease ;
>>Amoebiasis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Colorectal cancer ;
>>Renal cell carcinoma ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Chronic myeloid leukemia ;
>>Acute myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis