Purified recombinant human c-IAP2 protein fragments expressed in E.coli

This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.

birc3

AIP 1 ;
AIP1 ;
API 2 ;
API2 ;
API2 ;
Apoptosis inhibitor 2 ;
Baculoviral IAP repeat containing 3 ;
Baculoviral IAP repeat containing protein 3 ;
Baculoviral IAP repeat-containing protein 3 ;
BIRC 3 ;
BIRC3 ;
BIRC3 ;
BIRC3_HUMAN ;
C IAP2 ;
C-IAP2 ;
CIAP 2 ;
CIAP 2 ;
CIAP2 ;
HAIP 1 ;
HAIP1 ;
HAIP1 ;
HIAP 1 ;
HIAP-1 ;
HIAP1 ;
IAP homolog C ;
IAP-1 ;
Inhibitor of apoptosis protein 1 ;
Inhibitor of apoptosis protein 1 ;
MALT 2 ;
MALT2 ;
Mammalian IAP homolog C ;
MIHC ;
MIHC ;
RING finger protein 49 ;
RNF49 ;
TNFR2 TRAF signaling complex protein 1 ;
TNFR2 TRAF signalling complex protein ;
TNFR2-TRAF-signaling complex protein 1.

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],

Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.,

Cytoplasm . Nucleus .

>>Platinum drug resistance ;
>>NF-kappa B signaling pathway ;
>>Ubiquitin mediated proteolysis ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Necroptosis ;
>>Hippo signaling pathway ;
>>Focal adhesion ;
>>NOD-like receptor signaling pathway ;
>>TNF signaling pathway ;
>>Salmonella infection ;
>>Toxoplasmosis ;
>>Herpes simplex virus 1 infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Small cell lung cancer