Purified recombinant fragment of human VCAM-1 expressed in E. Coli.

VCAM-1 Monoclonal Antibody detects endogenous levels of VCAM-1 protein.

VCAM1

Vascular cell adhesion protein 1

VCAM1 ;
L1CAM ;
Vascular cell adhesion protein 1 ;
V-CAM 1 ;
VCAM-1 ;
INCAM-100 ;
CD antigen CD106

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010],

Alternative products:Additional isoforms seem to exist,Disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,Domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,Function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificity:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.,

Membrane; Single-pass type I membrane protein.

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

>>NF-kappa B signaling pathway ;
>>Cell adhesion molecules ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>African trypanosomiasis ;
>>Malaria ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis