Purified recombinant fragment of CD18 expressed in E. Coli.

CD18 Monoclonal Antibody detects endogenous levels of CD18 protein.

ITGB2

Integrin beta-2

ITGB2 ;
CD18 ;
MFI7 ;
Integrin beta-2 ;
Cell surface adhesion glycoproteins LFA-1/CR3/p150 ;
95 subunit beta ;
Complement receptor C3 subunit beta ;
CD antigen CD18

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.,

Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).

>>Rap1 signaling pathway ;
>>Phagosome ;
>>Hippo signaling pathway ;
>>Cell adhesion molecules ;
>>Complement and coagulation cascades ;
>>Neutrophil extracellular trap formation ;
>>Natural killer cell mediated cytotoxicity ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Pertussis ;
>>Legionellosis ;
>>Leishmaniasis ;
>>Malaria ;
>>Amoebiasis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Human T-cell leukemia virus 1 infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis