Purified recombinant Human CD131

This recombinant monoclonal antibody can detects endogenous levels of CD131 protein.

CSF2RB IL3RB IL5RB

Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)

IL-3R common β chain ;
CDw131 ;
Beta-C antibody ;
CD131 antibody ;
CDw131 antibody ;
Colony stimulating factor 2 receptor beta antibody ;
Colony stimulating factor 2 receptor beta low affinity ;
granulocyte macrophage ;
antibody ;
Common beta chain antibody ;
Csf2rb antibody ;
Cytokine receptor common beta chain antibody ;
Cytokine receptor common beta chain precursor ;
CDw131 antigen ;
antibody ;
Cytokine receptor common subunit beta antibody ;
GM CSF/IL 3/IL 5 receptor common beta chain antibody ;
GM-CSF/IL-3/IL-5 receptor common beta subunit antibody ;
granulocyte-macrophage colony-stimulating factor receptor ;
beta antibody ;
IL3RB antibody ;
IL3RB_HUMAN antibody ;
IL5RB antibody ;
Interleukin 3 receptor ;
beta antibody ;
Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta ;
high affinity ;
antibody ;
Interleukin 5 receptor ;
beta antibody ;
SMDP5 antibody ;
stimulating factor 3 receptor ;
beta ;
high affinity ;
antibody ;

CD131, also known as the IL-3R common β subunit , is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.

Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124).

Membrane; Single-pass type I membrane protein.