Cleaved Cathepsin L1 HC (Thr288) Cell-Based Colorimetric ELISA Kit
-KA3942C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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Cleaved Cathepsin L1 HC (Thr288) Cell-Based Colorimetric ELISA Kit
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抗原&靶点信息
基因名称:
CTSL1
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别名:
Cathepsin L1 ;
Major excreted protein ;
MEP ;
[Cleaved into: Cathepsin L1 heavy chain ;
Cathepsin L1 light chain]
Major excreted protein ;
MEP ;
[Cleaved into: Cathepsin L1 heavy chain ;
Cathepsin L1 light chain]
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背景:
catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,
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功能:
proteolysis,
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细胞定位:
Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .
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信号通路
Cellular Processes >> Transport and catabolism >> Phagosome
Cellular Processes >> Transport and catabolism >> Lysosome
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Immune system >> Antigen processing and presentation
Human Diseases >> Immune disease >> Rheumatoid arthritis
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