PML

Protein PML

PML ;
MYL ;
RNF71 ;
TRIM19 ;
Protein PML ;
Promyelocytic leukemia protein ;
RING finger protein 71 ;
Tripartite motif-containing protein 19

alternative products:Additional isoforms seem to exist ,disease:A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL) . Translocation t (15;17) (q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of an alternatively spliced exon. ,function:Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies. ,PTM:Sumoylated on all three sites is required for nuclear body formation. Sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65. The PML-RARA fusion protein is not sumoylated. ,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. ,similarity:Contains 1 RING-type zinc finger. ,similarity:Contains 2 B box-type zinc fingers. ,subcellular location:Sumoylated forms localize to the PML nuclear bodies. The B1 box and the RING finger are also required for this nuclear localization. Isoforms lacking a nuclear localization signal are cytoplasmic. ,subunit:Interacts with SIRT1 , TOPBP1 , TRIM27 and TRIM69. Interacts with the C-terminus of ELF4. Interacts with Lassa virus Z protein and rabies virus phosphoprotein. ,

protein import into nucleus , translocation , cell cycle checkpoint , DNA damage checkpoint , regulation of cell growth ,response to hypoxia , positive regulation of defense response to virus by host , immune system development ,regulation of immune effector process , regulation of response to biotic stimulus , DNA metabolic process , DNA repair ,transcription , regulation of translation , protein complex assembly , protein amino acid phosphorylation , protein targeting , protein import into nucleus , phosphorus metabolic process , phosphate metabolic process , intracellular protein transport , nucleocytoplasmic transport , apoptosis , induction of apoptosis , activation of caspase activity ,response to DNA damage stimulus , DNA damage response , signal transduction by p53 class mediator resulting in cell cycle arrest , response to oxidative stress , nucleus organization , cell cycle , cell cycle arrest , mitotic cell cycle checkpoint ,cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , common-partner SMAD protein phosphorylation , SMAD protein nuclear translocation , intracellular signaling cascade , regulation of mitotic cell cycle , aging , cell aging , protein localization , cell death , negative regulation of cell proliferation , regulation of cell size , induction of apoptosis by intracellular signals , DNA damage response , signal transduction resulting in induction of apoptosis , response to radiation , response to UV , response to light stimulus ,response to abiotic stimulus , negative regulation of biosynthetic process , response to organic substance , response to ionizing radiation , response to gamma radiation , negative regulation of macromolecule biosynthetic process ,regulation of cell cycle process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , negative regulation of gene expression , positive regulation of organelle organization , regulation of cell death , positive regulation of cell death ,positive regulation of peptidase activity , programmed cell death , induction of programmed cell death , protein transport , death , phosphorylation , negative regulation of transcription , negative regulation of angiogenesis , protein import , negative regulation of translation , cell cycle process , hemopoiesis , myeloid cell differentiation , negative regulation of cell growth , DNA damage response , signal transduction by p53 class mediator , intracellular receptor-mediated signaling pathway , nuclear body organization , PML body organization , regulation of histone modification ,positive regulation of histone modification , regulation of histone deacetylation , positive regulation of histone deacetylation , negative regulation of cellular biosynthetic process , regulation of protein modification process , positive regulation of protein modification process , DNA integrity checkpoint , G1 DNA damage checkpoint , G1/S transition checkpoint , regulation of protein stability , negative regulation of translation in response to stress , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , maintenance of protein location in cell , regulation of cellular component size ,negative regulation of translation in response to oxidative stress , regulation of organelle organization , regulation of chromosome organization , protein localization in organelle , cellular response to stress , response to cytokine stimulus ,protein localization in nucleus , cellular response to oxidative stress , cellular protein localization , regulation of growth ,regulation of cell proliferation , DNA damage response , signal transduction , DNA damage response , signal transduction by p53 class mediator resulting in induction of apoptosis , regulation of apoptosis , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of caspase activity , regulation of caspase activity , regulation of translation in response to stress , regulation of translation in response to oxidative stress , regulation of multi-organism process , macromolecular complex subunit organization , positive regulation of molecular function , establishment of protein localization ,maintenance of protein location , regulation of MHC class I biosynthetic process , regulation of transcription , regulation of angiogenesis , negative regulation of cell cycle , negative regulation of cell size , negative regulation of growth ,negative regulation of mitotic cell cycle , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , intracellular transport , retinoic acid receptor signaling pathway , hemopoietic or lymphoid organ development , regulation of defense response to virus , regulation of defense response to virus by host , protein stabilization , positive regulation of cellular component organization , nuclear transport , nuclear import , negative regulation of nitrogen compound metabolic process , maintenance of location , positive regulation of protein metabolic process , negative regulation of protein metabolic process , regulation of hydrolase activity , positive regulation of hydrolase activity , maintenance of protein location in nucleus , maintenance of location in cell , regulation of cell cycle ,regulation of peptidase activity , regulation of endopeptidase activity , macromolecular complex assembly , protein complex biogenesis , response to oxygen levels , cellular macromolecule localization ,

Nucleus. Nucleus , nucleoplasm. Cytoplasm . Nucleus , PML body . Nucleus , nucleolus. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2 , isoform PML-3 , isoform PML-4 , isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus , most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs) . The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein.