PTK2

Focal adhesion kinase 1 ;
FADK 1 ;
Focal adhesion kinase-related nonkinase ;
FRNK ;
Protein phosphatase 1 regulatory subunit 71 ;
PPP1R71 ;
Protein-tyrosine kinase 2 ;
p125FAK ;
pp125FAK ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,domain:The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions. ,domain:The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL. ,function:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility , proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking , or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid , or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. ,PTM:Phosphorylated on 6 tyrosine residues upon activation. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. ,similarity:Contains 1 FERM domain. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Constituent of focal adhesions. ,subunit:Interacts with CAS family members and with GIT1 , SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity) . Interacts with TGFB1I1. ,tissue specificity:Expressed in all organs tested , in lymphoid cell lines , but most abundantly in brain. ,

microtubule cytoskeleton organization , cell morphogenesis , cell morphogenesis involved in differentiation ,angiogenesis , blood vessel development , vasculogenesis , neuron migration , vasculature development , protein complex assembly , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,cell motion , cytoskeleton organization , microtubule-based process , cell surface receptor linked signal transduction ,enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , signal complex assembly , integrin-mediated signaling pathway , cell-cell signaling , synaptic transmission ,axonogenesis , negative regulation of cell development , regulation of cell morphogenesis involved in differentiation ,regulation of neuron projection development , phosphorylation , cell migration , transmission of nerve impulse , central nervous system neuron differentiation , central nervous system neuron development , central nervous system neuron axonogenesis , regulation of cell morphogenesis , cell projection organization , neuron differentiation , extracellular matrix organization , neuron projection development , regulation of cell projection organization , negative regulation of cell projection organization , cellular component morphogenesis , cell part morphogenesis , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , regulation of growth , establishment of nucleus localization , extracellular structure organization , endothelial cell migration , cellular protein complex assembly ,macromolecular complex subunit organization , regulation of cellular component biogenesis , negative regulation of cell differentiation , regulation of neuron differentiation , negative regulation of growth , regulation of organ growth ,negative regulation of organ growth , protein amino acid autophosphorylation , blood vessel morphogenesis , neuron development , cell morphogenesis involved in neuron differentiation , neuron projection morphogenesis , cell projection morphogenesis , cell motility , regulation of neurogenesis , negative regulation of neurogenesis , regulation of axonogenesis , negative regulation of axonogenesis , regulation of synapse structure and activity , regulation of synapse organization , neurological system process , negative regulation of cellular component organization , organelle localization , nucleus localization , establishment of organelle localization , localization of cell , regulation of nervous system development , negative regulation of nervous system development , regulation of synaptogenesis , negative regulation of synaptogenesis , regulation of cell development , macromolecular complex assembly , protein complex biogenesis ,

Cell junction , focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm , cell cortex. Cytoplasm , cytoskeleton. Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Nucleus. Cytoplasm , cytoskeleton , cilium basal body . Constituent of focal adhesions. Detected at microtubules.