PTPN6

Tyrosine-protein phosphatase non-receptor type 6 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1 ;

catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1 , induces UBE2V2 expression upon angiotensin II stimulation. ,PTM:Phosphorylated on serine and tyrosine residues. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,similarity:Contains 2 SH2 domains. ,subcellular location:In neurons , translocates into the nucleus after treatment with angiotensin II. ,subunit:Monomer. Interacts with MTUS1 (By similarity) . Binds PTPNS1 , LILRB1 and LILRB2. Interacts with FCRL2 , FCRL3 , FCRL4 , CD300LF and CD84. ,tissue specificity:Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells. ,

protein amino acid dephosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , cell death , negative regulation of cell proliferation , response to wounding , programmed cell death , death , dephosphorylation , regulation of cell proliferation ,

Cytoplasm. Nucleus. In neurons , translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1. .