STAT3 APRF

Signal transducer and activator of transcription 3 ;
Acute-phase response factor ;

disease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency , chronic eczema , recurrent Staphylococcal infections , increased serum IgE , eosinophilia , distinctive coarse facial appearance , abnormal dentition , hyperextensibility of the joints , and bone fractures. ,function:Transcription factor that binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. ,miscellaneous:Involved in the gp130-mediated signaling pathway. ,online information:STAT3 entry ,online information:STAT3 mutation db ,PTM:Tyrosine phosphorylated in response to IL-6 , IL-11 , CNTF , LIF , CSF-1 , EGF , PDGF , IFN-alpha and OSM. Phosphorylated on serine upon DNA damage , probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member (at least STAT1) . Interacts with NCOA1 , PELP1 , SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR. Interacts (via SH2 domain) with NLK (By similarity) . Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity) . Interacts with TMF1. ,tissue specificity:Heart , brain , placenta , lung , liver , skeletal muscle , kidney and pancreas. ,

negative regulation of transcription from RNA polymerase II promoter , eye development , temperature homeostasis ,eye photoreceptor cell differentiation , acute inflammatory response , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , cell motion , defense response , acute-phase response , inflammatory response , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade ,protein kinase cascade , JAK-STAT cascade , sensory organ development , behavior , feeding behavior , response to wounding , response to endogenous stimulus , response to hormone stimulus , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , response to organic cyclic substance , negative regulation of transcription , cytokine-mediated signaling pathway , sexual reproduction , neuron differentiation , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , response to estradiol stimulus ,cellular response to hormone stimulus , carbohydrate homeostasis , response to cytokine stimulus , regulation of growth , regulation of multicellular organism growth , response to drug , homeostatic process , glucose homeostasis ,eating behavior , response to peptide hormone stimulus , response to estrogen stimulus , regulation of transcription ,response to ethanol , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , photoreceptor cell differentiation ,response to steroid hormone stimulus , eye morphogenesis , multicellular organismal homeostasis , chemical homeostasis , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , growth hormone receptor signaling pathway , JAK-STAT cascade involved in growth hormone signaling pathway , response to growth hormone stimulus , interleukin-6-mediated signaling pathway ,

Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization , in response to signaling by activated FGFR1 , FGFR2 , FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation , accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.