FLI1/ERG (ABT-FLI1) Mouse mAb
-YM4928
主要信息
Target
FLI1
Host Species
Mouse
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
51kD (Observed)
Conjugate/Modification
Unmodified
货号: YM4928
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:100-500; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of FLI1 and ERG protein.
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
实测条带
51kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-FLI1
同种型
Mouse IgG1/Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human FLI1 AA range: 300-400
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特异性:
This antibody detects endogenous levels of FLI1 and ERG protein.
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基因名称:
FLI1
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蛋白名称:
Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB)
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背景:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t (11;22) (q24;q12) translocation with the Ewing sarcoma gene on chromosome 22 , which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t (4;11) (q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Aug 2012] ,
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功能:
Disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t (11;22) (q24;q12) with EWS. ,Function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. ,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t (4;11) (q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t (11;22) (q24;q12) breakpoint. ,similarity:Belongs to the ETS family. ,similarity:Contains 1 ETS DNA-binding domain. ,similarity:Contains 1 PNT (pointed) domain. ,subunit:Can form homodimers or heterodimers with ETV6/TEL1. ,
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细胞定位:
Nuclear
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组织表达:
研究领域:
>>Transcriptional misregulation in cancer
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文献引用（{{totalcount}}）
货号: YM4928
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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