The specific immunogen used to produce this antibody is proprietary information.

Endogenous

BSG

Basigin

BSG ;
Basigin ;
5F7 ;
Collagenase stimulatory factor ;
Extracellular matrix metalloproteinase inducer ;
EMMPRIN ;
Leukocyte activation antigen M6 ;
OK blood group antigen ;
Tumor cell-derived collagenase stimulatory factor ;
TCSF ;
CD antigen CD147

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis , embryo implantation , neural network formation , and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,

Function:Plays pivotal roles in spermatogenesis , embryo implantation , neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS) . May target monocarboxylate transporters SLC16A1 , SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro , promotes outgrowth of astrocytic processes. ,induction:Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. ,online information:Blood group antigen gene mutation database ,PTM:N-glycosylated. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subcellular location:Colocalizes with SLC16A1 and SLC16A8 (By similarity) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subunit:Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2 , MAG and L1CAM (By similarity) . Interacts with AJAP1. ,tissue specificity:Present only in vascular endothelium in non-neoplastic regions of the brain , whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas. ,

Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Photoreceptor inner segment . Cell projection , cilium , photoreceptor outer segment .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein . Endosome . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .