Endogenous

PDCD1 PD1

Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

CD279 ;
CD279 antigen ;
hPD 1 ;
hPD l ;
hPD-1 ;
hSLE1 ;
PD 1 ;
PD-1 ;
PD1 ;
PDCD 1 ;
PDCD1 ;
PDCD1_HUMAN ;
Programmed cell death 1 ;
Programmed cell death 1 protein ;
Programmed cell death protein 1 ;
Protein PD 1 ;
Protein PD-1 ;
SLEB2 ;
Systemic lupus erythematosus susceptibility 2

Programmed death-1 (PD-1) is an important immunosuppressive molecule. It is a member of CD28 superfamily. It is mainly expressed in germinal center related helper T cells and CD8 positive T cells. It includes tyrosine based inhibitory motif immune receptors, and plays an important role in peripheral immune tolerance mechanism and autoimmune diseases. PD-1 is a receptor for PD-L1 and PD-L2. Immune regulation targeting PD-1 is of great significance in anti-tumor, anti infection, anti autoimmune diseases and organ transplantation survival.

developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,

Membranous, Cytoplasmic

>>Cell adhesion molecules ;
>>T cell receptor signaling pathway ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer